Proteinase-activated Receptor 2 Promotes Cancer Cell Migration through RNA Methylation-mediated Repression of miR-125b

Yang, Lan; Ma, Yiming; Han, Wenxiao; Li, Weiwei; Cui, Liang; Zhao, Xinhua; Tian, Yantao; Zhou, Zhixiang; Wang, Wengong; Wang, Hongying

doi:10.1074/jbc.m115.667717

Public

Proteinase-activated Receptor 2 Promotes Cancer Cell Migration through RNA Methylation-mediated Repression of miR-125b

Published in Journal of Biological Chemistry • Sep 10, 2015

Authors:

Lan Yang

Yiming Ma

Wenxiao Han

Abstract

Proteinase activated-receptor 2 (PAR2) participates in cancer metastasis promoted by serine proteinases. The current study aimed to test the molecular mechanism by which PAR2 promotes cancer cell migration. In different cancer cells, activation of PAR2 by activating peptide (PAR2-AP) dramatically in...

Subject

Cell migration

Cancer cell

Cancer research

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