Ledipasvir and Sofosbuvir Plus Ribavirin for Treatment of HCV Infection in Patients With Advanced Liver Disease

Charlton, Michael; T. Everson, Gregory; L. Flamm, Steven; Kumar, Princy; Landis, Charles; S. Brown, Robert; Fried, Michael; A. Terrault, Norah; G. O’Leary, Jacqueline; E. Vargas, Hugo; Kuo, Alexander; R. Schiff, Eugene; Sulkowski, Mark; Gilroy, Richard; D. Watt, Kymberly; Brown, Kimberly; Y. Kwo, Paul; Pungpapong, Surakit; Korenblat, Kevin; J. Muir, Andrew; Teperman, Lewis; J. Fontana, Robert; Denning, Jill; Arterburn, Sarah; Dvory‐Sobol, Hadas; Brandt-Sarif, T.; S. Pang, Phillip; G. McHutchison, John; Rajender Reddy, K.; H. Afdhal, Nezam; Kumar, Princy; R. Schiff, Eugene; H. Afdhal, Nezam; S. Brown, R.; Fried, Michael; V. Kowdley, Kris; A. Terrault, Norah; Charlton, Michael; Y. Kwo, Paul; Flamm, S.; R. Lake, John; Everson, Greg; Sulkowski, Mark; P. Curry, Michael; Reddy, Rajender; Teperman, Lewis; E. Vargas, Hugo; Pungpapong, Surakit; J. Muir, Andrew; Zaman, Atif; Brown, Kimberly; Landis, Charles; Kuo, Alexander; J. Fontana, Robert; G. O’Leary, Jacqueline; Gilroy, Richard; S. Shaikh, Obaid; Korenblat, Kevin; T. Stravitz, Richard; D. Watt, Kymberly; Menon, Narayanan; E. Bredfeldt, James; Romero‐Marrero, Carlos

doi:10.1053/j.gastro.2015.05.010

Public

Ledipasvir and Sofosbuvir Plus Ribavirin for Treatment of HCV Infection in Patients With Advanced Liver Disease

Published in Gastroenterology • Jul 20, 2015

Authors:

Michael Charlton

Gregory T. Everson

Steven L. Flamm

Abstract

Background & AimsThere are no effective and safe treatments for chronic hepatitis C virus (HCV) infection of patients who have advanced liver disease.MethodsIn this phase 2, open-label study, we assessed treatment with the NS5A inhibitor ledipasvir, the nucleotide polymerase inhibitor sofosbuvir, an...

Subject

Sofosbuvir

Ribavirin

Ledipasvir

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