Essentiality of threonylcarbamoyladenosine (t<sup>6</sup><scp>A</scp>), a universal t<scp>RNA</scp> modification, in bacteria

C. Thiaville, Patrick; El Yacoubi, Basma; Köhrer, Caroline; J. Thiaville, Jennifer; Deutsch, Chris; Iwata‐Reuyl, Dirk; Marie Bacusmo, Jo; Armengaud, Jean; Bessho, Yoshitaka; Wetzel, Collin; Cao, Xiaoyu; A. Limbach, Patrick; L. RajBhandary, Uttam; de Crécy‐Lagard, Valérie

doi:10.1111/mmi.13209

Public

Essentiality of threonylcarbamoyladenosine (t6A), a universal tRNA modification, in bacteria

Published in Molecular Microbiology • Sep 4, 2015

Authors:

Patrick C. Thiaville

Basma El Yacoubi

Caroline Köhrer

Abstract

Threonylcarbamoyladenosine (t(6)A) is a modified nucleoside universally conserved in tRNAs in all three kingdoms of life. The recently discovered genes for t(6)A synthesis, including tsaC and tsaD, are essential in model prokaryotes but not essential in yeast. These genes had been identified as anti...

Subject

Biology

Deinococcus radiodurans

Thermus thermophilus

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