Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence

French, Leon; Gray, Courtney; Leonard, Gabriel; Perron, Michel; Bruce Pike, G.; Richer, Louis; R. Séguin, Jean; Veillette, Suzanne; Evans, John; Artiges, Éric; Banaschewski, Tobias; L.W. Bokde, Arun; Bromberg, Uli; Bruehl, Ruediger; Büchel, Christian; Cattrell, Anna; Conrod, Patricia; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Lemaître, Hervé; Martinot, Jean‐Luc; Nees, Frauke; Papadopoulos Orfanos, Dimitri; M. Pangelinan, Melissa; Poustka, Luise; Rietschel, Marcella; N. Smolka, Michael; Walter, Henrik; Whelan, Robert; J. Timpson, Nicholas; Schumann, Günter; Davey Smith, George; Pausová, Zdenka; Paus, Tomáš

doi:10.1001/jamapsychiatry.2015.1131

Public

Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence

Published in JAMA Psychiatry • Aug 26, 2015

Authors:

Leon French

Courtney Gray

Gabriel Leonard

Abstract

IMPORTANCE: Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure. OBJECTIVE: To evaluate wheth...

Subject

Cannabis

Polygenic risk score

Schizophrenia (object-oriented programming)

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