Phosphorylation of Eukaryotic Translation Initiation Factor 2Bε by Glycogen Synthase Kinase-3β Regulates β-Adrenergic Cardiac Myocyte Hypertrophy

E. Hardt, Stefan; Tomita, Hideharu; A. Katus, Hugo; Sadoshima, Junichi

doi:10.1161/01.res.0000124977.59827.80

Public

Phosphorylation of Eukaryotic Translation Initiation Factor 2Bε by Glycogen Synthase Kinase-3β Regulates β-Adrenergic Cardiac Myocyte Hypertrophy

Published in Circulation Research • Mar 9, 2004

Authors:

Stefan E. Hardt

Hideharu Tomita

Hugo A. Katus

Abstract

Glycogen synthase kinase 3beta (GSK-3beta) negatively regulates cardiac hypertrophy. A potential target mediating the antihypertrophic effect of GSK-3beta is eukaryotic translation initiation factor 2Bepsilon (eIF2Bepsilon). Overexpression of GSK-3beta increased the cellular kinase activity toward G...

Subject

Cardiac myocyte

GSK-3

Glycogen synthase

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