Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

Álvarez, Alejandra; Alarcón, Rodrigo; Opazo, Carlos; O. Campos, Eliseo; J. Muñoz, Francisco; Calderón, Frances; Dajas, Federico; K. Gentry, Mary; P. Doctor, Bhupendra; G. de Mello, Fernando; C. Inestrosa, Nibaldo

doi:10.1523/jneurosci.18-09-03213.1998

Public

Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

Published in Journal of Neuroscience • May 1, 1998

Authors:

Alejandra Álvarez

Rodrigo Alarcón

Carlos Opazo

Abstract

Brain acetylcholinesterase (AChE) forms stable complexes with amyloid-beta peptide (Abeta) during its assembly into filaments, in agreement with its colocalization with the Abeta deposits of Alzheimer's brain. The association of the enzyme with nascent Abeta aggregates occurs as early as after 30 mi...

Subject

Acetylcholinesterase

Neurotoxicity

Chemistry

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