Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain.

C, Zhu; L, Qiu; X, Wang; U, Hallin; C, Candé; G, Kroemer; H, Hagberg; K, Blomgren

doi:10.1046/j.1471-4159.2003.01832.x

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Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain.

Shared by NobleBlocks on Jul 1, 2003 • 12:00 AM UTC

Authors:

Zhu C

Qiu L

Wang X

Abstract

Apoptosis-inducing factor (AIF) triggers apoptosis in a caspase-independent manner. Here we report for the first time involvement of AIF in neuronal death induced by cerebral ischemia. Unilateral cerebral hypoxia-ischemia (HI) was induced in 7-day-old rats by ligation of the left carotid artery and ...

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