Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages

A. Filardy, Alessandra; R. Pires, Dayana; P. Nunes, Marise; Maeda Takiya, Christina; Geraldo Freire-de-Lima, Célio; Lima Ribeiro-Gomes, Flávia; A. DosReis, George

doi:10.4049/jimmunol.1000017

Public

Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages

Published in The Journal of Immunology • Jul 21, 2010

Authors:

Alessandra A. Filardy

Dayana R. Pires

Marise P. Nunes

Abstract

Clearance of apoptotic exudate neutrophils (efferocytosis) induces either pro- or anti-inflammatory responses in mouse macrophages depending on host genetic background. In this study, we investigated whether neutrophil efferocytosis induces a stable macrophage phenotype that could be recalled by lat...

Subject

Efferocytosis

Biology

Cell biology

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