Inhibition of Neutrophil Apoptosis by TLR Agonists in Whole Blood: Involvement of the Phosphoinositide 3-Kinase/Akt and NF-κB Signaling Pathways, Leading to Increased Levels of Mcl-1, A1, and Phosphorylated Bad

François, Stéphanie; El‐Benna, Jamel; My‐Chan Dang, Pham; Pédruzzi, Eric; Gougerot‐Pocidalo, Marie‐Anne; Elbim, Carole

doi:10.4049/jimmunol.174.6.3633

Public

Inhibition of Neutrophil Apoptosis by TLR Agonists in Whole Blood: Involvement of the Phosphoinositide 3-Kinase/Akt and NF-κB Signaling Pathways, Leading to Increased Levels of Mcl-1, A1, and Phosphorylated Bad

Published in The Journal of Immunology • Mar 1, 2005

Authors:

Stéphanie François

Jamel El‐Benna

Pham My‐Chan Dang

Abstract

Using flow cytometry, we investigated the effect of TLR agonists on human polymorphonuclear neutrophil (PMN) apoptosis in whole blood. LPS (TLR4), peptidoglycan (TLR2), R-848 (TLR7/8), and CpG-DNA (TLR9) were equally effective at delaying spontaneous apoptosis of PMN, while PamCSK4 (TLR1/2), macroph...

Subject

PI3K/AKT/mTOR pathway

TLR2

Protein kinase B

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