Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2

J.-D. Hsieh, James; Henkel, Thomas; Salmon, Patrick; A. Robey, Ellen; Gregory Peterson, Michael; Diane Hayward, S.

doi:10.1128/mcb.16.3.952

Public

Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2

Published in Molecular and Cellular Biology • Mar 1, 1996

Authors:

James J.-D. Hsieh

Thomas Henkel

Patrick Salmon

Abstract

The Notch/Lin-12/Glp-1 receptor family participates in cell-cell signaling events that influence cell fate decisions. Although several Notch homologs and receptor ligands have been identified, the nuclear events involved in this pathway remain incompletely understood. A truncated form of Notch, cons...

Subject

Biology

Ankyrin repeat

Transactivation

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