Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis

Bertrand, A; Kostine, Marie; Barnetche, Thomas; Truchetet, Marie‐Elise; Schaeverbeke, Thierry

doi:10.1186/s12916-015-0455-8

Public

Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis

Published in BMC Medicine • Sep 3, 2015

Authors:

A Bertrand

Marie Kostine

Thomas Barnetche

Abstract

BACKGROUND: Targeting CTLA-4 is a recent strategic approach in cancer control: blocking CTLA-4 enhances an antitumor immunity by promoting T-cell activation and cytotoxic T-lymphocyte proliferation. This induction of a tolerance break against the tumor may be responsible for immune-related adverse e...

Subject

Medicine

Ipilimumab

Internal medicine

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!