Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

Mutanu Jungersted, Jakob; Sophie Scheer, Helene; Mempel, Martin; Baurecht, Hansjörg; Cifuentes, Lorena; K. Høgh, J.; Hellgren, Lars; B. E. Jemec, Gregor; Agner, Tove; Weidinger, Stephan

doi:10.1111/j.1398-9995.2010.02326.x

Public

Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

Published in Allergy • Feb 4, 2010

Authors:

Jakob Mutanu Jungersted

Helene Sophie Scheer

Martin Mempel

Abstract

BACKGROUND: Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic dermatitis (AD) has been documented, and changes in ceramide profile, altered skin pH and increased trans-epidermal water loss (TEWL) in patients with AD have been reported. Until now, no...

Subject

Ceramide

Stratum corneum

Filaggrin

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