Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

Onishi, Mayumi; Nosaka, Tetsuya; Misawa, Kazuhide; Mui, Alice; M. Gorman, Daniel; McMahon, Martin; Miyajima, Atsushi; Kitamura, Toshio

doi:10.1128/mcb.18.7.3871

Public

Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

Published in Molecular and Cellular Biology • Jul 1, 1998

Authors:

Mayumi Onishi

Tetsuya Nosaka

Kazuhide Misawa

Abstract

STAT (signal transducers and activators of transcription) proteins are transcription factors which are activated by phosphorylation on tyrosine residues upon stimulation by cytokines. Seven members of the STAT family are known, including the closely related STAT5A and STAT5B, which are activated by ...

Subject

STAT5

Biology

Transactivation

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