Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Arellano, Gabriel; A. Ottum, Payton; I. Reyes, Lilian; I. Burgos, Paula; Naves, Rodrigo

doi:10.3389/fimmu.2015.00492

Public

Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Published in Frontiers in Immunology • Sep 29, 2015

Authors:

Gabriel Arellano

Payton A. Ottum

Lilian I. Reyes

Abstract

The role of interferon (IFN)-γ in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), has remained as an enigmatic paradox for more than 30 years. Several studies attribute this cytokine a prominent proinflammatory and pathogenic function in these pathologi...

Subject

Experimental autoimmune encephalomyelitis

Multiple sclerosis

Immunology

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