Mapping Loci for Pentylenetetrazol-Induced Seizure Susceptibility in Mice

N. Ferraro, Thomas; T. Golden, Gregory; Gilbert Smith, George; St. Jean, Pamela; J. Schork, Nicholas; Mulholland, Nicole; Ballas, Christos; F. Schill, J.; J. Buono, Russell; H. Berrettini, Wade

doi:10.1523/jneurosci.19-16-06733.1999

Public

Mapping Loci for Pentylenetetrazol-Induced Seizure Susceptibility in Mice

Published in Journal of Neuroscience • Aug 15, 1999

Authors:

Thomas N. Ferraro

Gregory T. Golden

George Gilbert Smith

Abstract

DBA/2J (D2) and C57BL/6J (B6) mice exhibit differential sensitivity to seizures induced by various chemical and physical methods, with D2 mice being relatively sensitive and B6 mice relatively resistant. We conducted studies in mature D2, B6, F1, and F2 intercross mice to investigate behavioral seiz...

Subject

Pentylenetetrazol

Clonus

Kainic acid

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