Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies

Kurdiová, Tímea; Baláž, Miroslav; Vician, M; Máderová, Denisa; Vlček, Miroslav; Valkovič, Ladislav; Srbecký, Miroslav; Imrich, Richard; Kyselovičová, Oľga; Belan, V.; Jelok, I; Wolfrum, Christian; Klimeś, I; Krššák, Martin; Zemková, Erika; Gašperíková, Daniela; Ukropec, Jozef; Ukropcová, Barbara

doi:10.1113/jphysiol.2013.264655

Public

Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies

Published in The Journal of Physiology • Dec 3, 2013

Authors:

Tímea Kurdiová

Miroslav Baláž

M Vician

Abstract

Key points Considerable controversy exists regarding the role of irisin, a putative exercise‐induced myokine, in human metabolism. We therefore studied irisin and its precursor Fndc5 in obesity, type 2 diabetes and exercise. Complex clinical studies combined with cell culture work revealed that Fndc...

Subject

FNDC5

Endocrinology

Internal medicine

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