Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

Caro‐Maldonado, Alfredo; Wang, Ruoning; Nichols, Amanda; Kuraoka, Masayuki; Milasta, Sandra; Sun, Lillian; L. Gavin, Amanda; Dale Abel, E.; Kelsoe, Garnett; R. Green, Douglas; C. Rathmell, Jeffrey

doi:10.4049/jimmunol.1302062

Public

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

Published in The Journal of Immunology • Mar 11, 2014

Authors:

Alfredo Caro‐Maldonado

Ruoning Wang

Amanda Nichols

Abstract

B cell activation leads to proliferation and Ab production that can protect from pathogens or promote autoimmunity. Regulation of cell metabolism is essential to support the demands of lymphocyte growth and effector function and may regulate tolerance. In this study, we tested the regulation and rol...

Subject

Glycolysis

GLUT1

Cell biology

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