Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues

R. Parkhurst, Maria; L. Salgaller, Michael; Southwood, Scott; F. Robbins, Paul; Sette, Alessandro; A. Rosenberg, Steven; Kawakami, Yutaka

doi:10.4049/jimmunol.157.6.2539

Public

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues

Published in The Journal of Immunology • Sep 1, 1996

Authors:

Maria R. Parkhurst

Michael L. Salgaller

Scott Southwood

Abstract

Recognition of the melanoma Ag gp100 by tumor-infiltrating lymphocytes (TIL) in vitro has been correlated with tumor regression in patients with metastatic melanoma treated with the adoptive transfer of TIL plus IL-2. Three common gp100 epitopes have been identified that are recognized in the contex...

Subject

CTL*

Epitope

Immunogenicity

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!