Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

Kawarabayashi, Takeshi; H. Younkin, Linda; C. Saido, Takaomi; Shoji, Mikio; H. Ashe, Karen; G. Younkin, Steven

doi:10.1523/jneurosci.21-02-00372.2001

Public

Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

Published in Journal of Neuroscience • Jan 15, 2001

Authors:

Takeshi Kawarabayashi

Linda H. Younkin

Takaomi C. Saido

Abstract

The accumulation of amyloid beta protein (Abeta) in the Tg2576 mouse model of Alzheimer's disease (AD) was evaluated by ELISA, immunoblotting, and immunocytochemistry. Changes in Abeta begin at 6-7 months as SDS-insoluble forms of Abeta42 and Abeta40 that require formic acid for solubilization appea...

Subject

Senile plaques

Genetically modified mouse

Amyloid (mycology)

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