Transmission of innate immune signaling by packaging of cGAMP in viral particles

Gentili, Matteo; Kowal, Joanna; Tkach, Mercedes; Satoh, Takeshi; Lahaye, Xavier; Conrad, Cécile; Boyron, Marilyn; Lombard, Bérangère; Durand, Sylvère; Kroemer, Guido; Loew, Damarys; Dalod, Marc; Théry, Clotilde; Manel, Nicolas

doi:10.1126/science.aab3628

Public

Transmission of innate immune signaling by packaging of cGAMP in viral particles

Published in Science • Jul 30, 2015

Authors:

Matteo Gentili

Joanna Kowal

Mercedes Tkach

Abstract

Infected cells detect viruses through a variety of receptors that initiate cell-intrinsic innate defense responses. Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) is a cytosolic sensor for many DNA viruses and HIV-1. In response to cytosolic viral DNA, cGAS synthe...

Subject

Innate immune system

Host (biology)

Immune system

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