Randomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study

W. Whitney, Charles; T. Sause, William; N. Bundy, Brian; H. Malfetano, John; V. Hannigan, Edward; C. Fowler, Wesley; L. Clarke‐Pearson, Daniel; Liao, Shu‐Yuan

doi:10.1200/jco.1999.17.5.1339

Public

Randomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study

Published in Journal of Clinical Oncology • May 1, 1999

Authors:

Charles W. Whitney

William T. Sause

Brian N. Bundy

Abstract

PURPOSE: In 1986, a protocol comparing primary radiation therapy (RT) plus hydroxyurea (HU) to irradiation plus fluorouracil (5-FU) and cisplatin (CF) was activated by the Gynecologic Oncology Group (GOG) for the treatment of patients with locally advanced cervical carcinoma. The goals were to deter...

Subject

Medicine

Gynecologic oncology

Internal medicine

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