Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein

A. Bradford, Patricia; Urban, Carl; Mariano, N; J. Projan, Steven; J. Rahal, James; Bush, Karen

doi:10.1128/aac.41.3.563

Public

Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein

Published in Antimicrobial Agents and Chemotherapy • Mar 1, 1997

Authors:

Patricia A. Bradford

Carl Urban

N Mariano

Abstract

Six Escherichia coli and 12 Klebsiella pneumoniae isolates from a single hospital expressed a common beta-lactamase with a pI of approximately 9.0 and were resistant to cefoxitin and cefotetan (MIC ranges, 64 to > 128 and 16 to > 128 micrograms/ml, respectively). Seventeen of the 18 strains produced...

Subject

Imipenem

Klebsiella pneumoniae

Microbiology

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