IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease.

S. Via, Charles; Rus, Violeta; K. Gately, Maurice; D Finkelman, F

doi:10.4049/jimmunol.153.9.4040

Public

IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease.

Shared by NobleBlocks on Nov 1, 1994 • 12:00 AM UTC

Authors:

Charles S. Via

Violeta Rus

Maurice K. Gately

Abstract

The injection of DBA/2 (D2) spleen cells into (C57BL/6 x DBA/2)F1 mice (BDF1) induces a chronic, autoimmune graft-vs-host disease (GVHD) that is characterized by: increased production of Th2-associated cytokines; increased levels of serum Ig, including IgE; increased production of IgG anti-DNA Abs; ...

Subject

Immunology

CTL*

Immune system

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