PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

T. Le, Dung; N. Uram, Jennifer; Wang, Hao; R. Bartlett, Bjarne; Kemberling, Holly; Eyring, Aleksandra; D. Skora, Andrew; Luber, Brandon; S. Azad, Nilofer; Laheru, Dan; Biedrzycki, Barbara; C. Donehower, Ross; Zaheer, Atif; A. Fisher, George; S. Crocenzi, Todd; J. Lee, James; M. Duffy, Steven; M. Goldberg, Richard; de la Chapelle, Albert; Koshiji, Minori; Bhaijee, Feriyl; Huebner, Thomas; H. Hruban, Ralph; D. Wood, Laura; Cuka, Nathan; M. Pardoll, Drew; Papadopoulos, Nickolas; W. Kinzler, Kenneth; Zhou, Shibin; C. Cornish, Toby; M. Taube, Janis; A. Anders, Robert; R. Eshleman, James; Vogelstein, Bert; A. Díaz, Luis

doi:10.1056/nejmoa1500596

Public

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Published in New England Journal of Medicine • May 30, 2015

Authors:

Dung T. Le

Jennifer N. Uram

Hao Wang

Abstract

BACKGROUND: Somatic mutations have the potential to encode "non-self" immunogenic antigens. We hypothesized that tumors with a large number of somatic mutations due to mismatch-repair defects may be susceptible to immune checkpoint blockade. METHODS: We conducted a phase 2 study to evaluate the clin...

Subject

Medicine

Pembrolizumab

DNA mismatch repair

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