TLR2 Is Constitutively Expressed within the Kidney and Participates in Ischemic Renal Injury through Both MyD88-Dependent and -Independent Pathways

A. Shigeoka, Alana; Holscher, Todd; J. King, Andrew; W. Hall, Frank; B. Kiosses, William; S. Tobias, Peter; Mackman, Nigel; B. McKay, Dianne

doi:10.4049/jimmunol.178.10.6252

Public

TLR2 Is Constitutively Expressed within the Kidney and Participates in Ischemic Renal Injury through Both MyD88-Dependent and -Independent Pathways

Published in The Journal of Immunology • May 1, 2007

Authors:

Alana A. Shigeoka

Todd Holscher

Andrew J. King

Abstract

TLRs are an evolutionarily conserved family of cell membrane proteins believed to play a significant role in innate immunity and the response to tissue injury, including that induced by ischemia. TLR signaling pathways activate transcription factors that regulate expression of prosurvival proteins, ...

Subject

TRIF

TLR2

Signal transducing adaptor protein

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