A capsule-deficient mutant of Francisella tularensis LVS exhibits enhanced sensitivity to killing by serum but diminished sensitivity to killing by polymorphonuclear leukocytes

Sandström, Gunnar; Löfgren, Sture; Tärnvik, Arne

doi:10.1128/iai.56.5.1194-1202.1988

Public

A capsule-deficient mutant of Francisella tularensis LVS exhibits enhanced sensitivity to killing by serum but diminished sensitivity to killing by polymorphonuclear leukocytes

Published in Infection and Immunity • May 1, 1988

Authors:

Gunnar Sandström

Sture Löfgren

Arne Tärnvik

Abstract

The live vaccine strain (LVS) of Francisella tularensis is killed by human polymorphonuclear leukocytes as a result of strictly oxygen-dependent mechanisms (S. Löfgren, A. Tärnvik, M. Thore, and J. Carlsson, Infect. Immun. 43:730-734, 1984). We now report that a capsule-deficient (Cap-) mutant of LV...

Subject

Francisella tularensis

Biology

Antibody opsonization

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