Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

Y. Shih, Andy; A. Johnson, Delinda; Wong, Gloria; D. Kraft, Andrew; Jiang, Lei; Erb, Heidi; A. Johnson, Jeffrey; H. Murphy, Timothy

doi:10.1523/jneurosci.23-08-03394.2003

Public

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

Published in Journal of Neuroscience • Apr 15, 2003

Authors:

Andy Y. Shih

Delinda A. Johnson

Gloria Wong

Abstract

Astrocytes have a higher antioxidant potential in comparison to neurons. Pathways associated with this selective advantage include the transcriptional regulation of antioxidant enzymes via the action of the Cap'n'Collar transcription factor Nrf2 at the antioxidant response element (ARE). Here we sho...

Subject

Glutathione

Oxidative stress

Glutathione reductase

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