Connective tissue growth factor mediates transforming growth factor β‐induced collagen synthesis: down‐regulation by cAMP

R. Duncan, Matthew; Frazier, Ken; Abramson, Susan; Williams, S.; Klapper, Helene; Huang, Xinfan; R. Grotendorst, Gary

doi:10.1096/fasebj.13.13.1774

Public

Connective tissue growth factor mediates transforming growth factor β‐induced collagen synthesis: down‐regulation by cAMP

Published in The FASEB Journal • Oct 1, 1999

Authors:

Matthew R. Duncan

Ken Frazier

Susan Abramson

Abstract

Connective tissue growth factor (CTGF) is a cysteine-rich peptide synthesized and secreted by fibroblastic cells after activation with transforming growth factor beta (TGF-beta) that acts as a downstream mediator of TGF-beta-induced fibroblast proliferation. We performed in vitro and in vivo studies...

Subject

CTGF

Growth factor

Connective tissue

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