The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic

Ferlazzo, Guido; Thomas, Dolca; Lin, Shao-Lee; Goodman, Kiera; Morandi, Barbara; A Muller, William; Moretta, Alessandro; Münz, Christian

doi:10.4049/jimmunol.172.3.1455

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The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic

Shared by NobleBlocks on Feb 1, 2004 • 12:00 AM UTC

Authors:

Guido Ferlazzo

Dolca Thomas

Shao-Lee Lin

Abstract

Abstract Natural killer cells are important cytolytic cells in innate immunity. We have characterized human NK cells of spleen, lymph nodes, and tonsils. More than 95% of peripheral blood and 85% of spleen NK cells are CD56dimCD16+ and express perforin, the natural cytotoxicity receptors (NCRs) NKp3...

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