A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19<sup>+</sup>tumor cells

Reusch, Uwe; Duell, Johannes; Ellwanger, Kristina; Herbrecht, Carmen; Knackmuss, Stefan; Fucek, Ivica; Eser, Markus; McAleese, Fionnuala; Molkenthin, Vera; Le Gall, Fabrice; S. Topp, Max; Little, Melvyn; A. Zhukovsky, Eugene

doi:10.1080/19420862.2015.1029216

Public

A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19+tumor cells

Published in mAbs • Apr 15, 2015

Authors:

Uwe Reusch

Johannes Duell

Kristina Ellwanger

Abstract

To harness the potent tumor-killing capacity of T cells for the treatment of CD19(+) malignancies, we constructed AFM11, a humanized tetravalent bispecific CD19/CD3 tandem diabody (TandAb) consisting solely of Fv domains. The molecule exhibits good manufacturability and stability properties. AFM11 h...

Subject

CD19

CD3

Antigen

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