Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Zeggini, Eleftheria; N. Weedon, Michael; M. Lindgren, Cecilia; M. Frayling, Timothy; S. Elliott, Katherine; Lango Allen, Hana; J. Timpson, Nicholas; R. B. Perry, John; W. Rayner, Nigel; M. Freathy, Rachel; C. Barrett, Jeffrey; M. Shields, Beverley; P. Morris, Andrew; Ellard, Sian; J. Groves, Christopher; W. Harries, Lorna; Marchini, Jonathan; R. Owen, Katharine; Knight, Beatrice; R. Cardon, Lon; Walker, Mark; A. Hitman, G.; D. Morris, Andrew; S. F. Doney, Alex; I. McCarthy, Mark; T. Hattersley, Andrew

doi:10.1126/science.1142364

Public

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Published in Science • Apr 26, 2007

Authors:

Eleftheria Zeggini

Michael N. Weedon

Cecilia M. Lindgren

Abstract

The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set out to detect replicated diabetes association si...

Subject

TCF7L2

Type 2 diabetes

Biology

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