Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression

Nomura, Fumiko; Akashi, Sachiko; Sakao, Yoshimitsu; Sato, Shintaro; Kawai, Taro; Matsumoto, Makoto; Nakanishi, Kenji; Kimoto, Masao; Miyake, Kensuke; Takeda, Kiyoshi; Akira, Shizuo

doi:10.4049/jimmunol.164.7.3476

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Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression

Published in The Journal of Immunology • Apr 1, 2000

Authors:

Fumiko Nomura

Sachiko Akashi

Yoshimitsu Sakao

Abstract

Monocytes/macrophages exposed to LPS show reduced responses to second stimulation with LPS, which is termed LPS tolerance. In this study, we investigated molecular mechanism of LPS tolerance in macrophages. Mouse peritoneal macrophages pre-exposed to LPS exhibited reduced production of inflammatory ...

Subject

TLR4

Lipopolysaccharide

Toll-like receptor

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