Myeloid-Derived Suppressor Cells Accumulate in Kidney Allograft Tolerance and Specifically Suppress Effector T Cell Expansion

Dugast, Anne‐Sophie; Haudebourg, Thomas; Coulon, Flora; Heslan, Michèle; Haspot, Fabienne; Poirier, Nicolas; Vuillefroy de Silly, Romain; Usal, Claire; Smit, Helga; Martinet, Bernard; Thébault, Paméla; Renaudin, Karine; Vanhove, Bernard

doi:10.4049/jimmunol.180.12.7898

Public

Myeloid-Derived Suppressor Cells Accumulate in Kidney Allograft Tolerance and Specifically Suppress Effector T Cell Expansion

Published in The Journal of Immunology • Jun 1, 2008

Authors:

Anne‐Sophie Dugast

Thomas Haudebourg

Flora Coulon

Abstract

The immune tolerance to rat kidney allografts induced by a perioperative treatment with anti-CD28 Abs is associated with a severe unresponsiveness of peripheral blood cells to donor Ags. In this model, we identified an accumulation in the blood of CD3(-)class II(-)CD11b(+)CD80/86(+) plastic-adherent...

Subject

CD80

Myeloid-derived Suppressor Cell

CD28

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