Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions

Glogauer, Michael; C. Marchal, Christophe; Zhu, Fei; Worku, Aelaf; E. Clausen, Björn; Foerster, Irmgard; Marks, Peter; P. Downey, Gregory; C. Dinauer, Mary; J. Kwiatkowski, David

doi:10.4049/jimmunol.170.11.5652

Public

Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions

Published in The Journal of Immunology • Jun 1, 2003

Authors:

Michael Glogauer

Christophe C. Marchal

Fei Zhu

Abstract

Defects in myeloid cell function in Rac2 knockout mice underline the importance of this isoform in activation of NADPH oxidase and cell motility. However, the specific role of Rac1 in neutrophil function has been difficult to assess since deletion of Rac1 results in embryonic lethality in mice. To e...

Subject

RAC1

Chemotaxis

NADPH oxidase

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