ASSOCIATION BETWEEN MUTATIONS IN PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER AND P. FALCIPARUM MULTIDRUG RESISTANCE 1 GENES AND IN VIVO AMODIAQUINE RESISTANCE IN P. FALCIPARUM MALARIA–INFECTED CHILDREN IN NIGERIA

Happi, Christian; O. Gbotosho, Grace; Folarin, Onikepe; Bolaji, Olayinka; Sowunmi, A.; E. Kyle, Dennis; K. Milhous, Wilbur; F. Wirth, Dyann; M. J. Oduola, A.

doi:10.4269/ajtmh.2006.75.155

Public

ASSOCIATION BETWEEN MUTATIONS IN PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER AND P. FALCIPARUM MULTIDRUG RESISTANCE 1 GENES AND IN VIVO AMODIAQUINE RESISTANCE IN P. FALCIPARUM MALARIA–INFECTED CHILDREN IN NIGERIA

Shared by NobleBlocks on Jul 1, 2006 • 12:00 AM UTC

Authors:

Christian Happi

Grace O. Gbotosho

Onikepe Folarin

Abstract

This study investigated the association between Plasmodium falciparum chloroquine resistance transporter (pfcrt) T76 and P. falciparum multidrug resistance gene 1 (pfmdr1) Y86 alleles and in vivo amodiaquine (AQ) resistance, as well as the clearance of parasites harboring these two alleles in childr...

Subject

Plasmodium falciparum

Amodiaquine

Malaria

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