Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients

Ziv, Elad; Déan, Eric; Hu, Donglei; Di Martino, Alessandro; Serie, Daniel; Curtin, Karen; Campa, Daniele; T. Aftab, Blake; M. Bracci, Paige; Buda, Gabriele; Zhao, Yi; L. Caswell‐Jin, Jennifer; B. Diasio, Robert; Dumontet, Charles; Dudziński, Marek; Fejerman, Laura; J. Greenberg, Alexandra; Huntsman, Scott; Jamroziak, Krzysztof; Jurczyszyn, Artur; Kumar, Shaji; Atanackovic, Djordje; Glenn, Martha; Cannon‐Albright, Lisa; Jones, Brandt; Lee, Adam; Marques, Herlander; G. Martin, Thomas; Martínez‐López, Joaquín; Vincent Rajkumar, S.; Sáinz, Juan; Juul Vangsted, Annette; Wątek, Marzena; L. Wolf, Jeffrey; L. Slager, Susan; J. Camp, Nicola; Canzian, Federico; M. Vachon, Celine

doi:10.1038/ncomms8539

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Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients

Published in Nature Communications • Jul 22, 2015

Authors:

Elad Ziv

Eric Déan

Donglei Hu

Abstract

Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs...

Subject

Genome-wide association study

Minor allele frequency

Single-nucleotide polymorphism

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