Live-cell superresolution microscopy reveals the organization of RNA polymerase in the bacterial nucleoid

Stracy, Mathew; Lesterlin, Christian; Garza de León, Federico; Uphoff, Stephan; Zawadzki, Paweł; N. Kapanidis, Achillefs

doi:10.1073/pnas.1507592112

Public

Live-cell superresolution microscopy reveals the organization of RNA polymerase in the bacterial nucleoid

Published in Proceedings of the National Academy of Sciences • Jul 29, 2015

Authors:

Mathew Stracy

Christian Lesterlin

Federico Garza de León

Abstract

Despite the fundamental importance of transcription, a comprehensive analysis of RNA polymerase (RNAP) behavior and its role in the nucleoid organization in vivo is lacking. Here, we used superresolution microscopy to study the localization and dynamics of the transcription machinery and DNA in live...

Subject

Nucleoid

Superresolution

Bacterial cell structure

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