Mechanism of Toxicity in Rotenone Models of Parkinson's Disease

Sherer, Todd; Betarbet, Ranjita; Testa, Claudia; Boo Seo, Byoung; R. Richardson, Jason; Ho Kim, Jin; W. Miller, Gary; Yagi, Takao; Matsuno‐Yagi, Akemi; Timothy Greenamyre, J.

doi:10.1523/jneurosci.23-34-10756.2003

Public

Mechanism of Toxicity in Rotenone Models of Parkinson's Disease

Published in Journal of Neuroscience • Nov 26, 2003

Authors:

Todd Sherer

Ranjita Betarbet

Claudia Testa

Abstract

Exposure of rats to the pesticide and complex I inhibitor rotenone reproduces features of Parkinson's disease, including selective nigrostriatal dopaminergic degeneration and alpha-synuclein-positive cytoplasmic inclusions (Betarbet et al., 2000; Sherer et al., 2003). Here, we examined mechanisms of...

Subject

Rotenone

Biology

Dopaminergic

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