The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone

Samer, Caroline; Daali, Youssef; Wagner, Michel; Hopfgartner, Gérard; B. Eap, Chin; Rebsamen, M.; Rossier, MF; Hochstrasser, D; Dayer, Pierre; Desmeules, JA

doi:10.1111/j.1476-5381.2010.00673.x

Public

The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone

Published in British Journal of Pharmacology • May 24, 2010

Authors:

Caroline Samer

Youssef Daali

Michel Wagner

Abstract

BACKGROUND AND PURPOSE: There is high interindividual variability in the activity of drug-metabolizing enzymes catalysing the oxidation of oxycodone [cytochrome P450 (CYP) 2D6 and 3A], due to genetic polymorphisms and/or drug-drug interactions. The effects of CYP2D6 and/or CYP3A activity modulation ...

Subject

Oxymorphone

Oxycodone

Pharmacology

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