Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases.

Aubé, Benoit; A Lévesque, Sébastien; Paré, Alexandre; Chamma, Émilie; Kébir, Hania; Gorina, Roser; Lécuyer, Marc-André; I Alvarez, Jorge; De Koninck, Yves; Engelhardt, Britta; Prat, Alexandre; Côté, Daniel; Lacroix, Steve

doi:10.4049/jimmunol.1400401

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Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases.

Published in Journal of immunology (Baltimore, Md. : 1950) • Sep 1, 2014

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Authors:

Benoit Aubé

,

Sébastien A Lévesque

,

Alexandre Paré

Abstract

Disruption of the blood-brain and blood-spinal cord barriers (BBB and BSCB, respectively) and immune cell infiltration are early pathophysiological hallmarks of multiple sclerosis (MS), its animal model experimental autoimmune encephalomyelitis (EAE), and neuromyelitis optica (NMO). However, their c...

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