Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni

L. Ranasinghe, Shiwanthi; Fischer, Katja; N. Gobert, Geoffrey; P. McManus, Donald

doi:10.1186/s13071-015-1022-z

Public

Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni

Published in Parasites & Vectors • Aug 3, 2015

Authors:

Shiwanthi L. Ranasinghe

Katja Fischer

Geoffrey N. Gobert

Abstract

BACKGROUND: Schistosomes are able to survive for prolonged periods in the blood system, despite continuous contact with coagulatory factors and mediators of the host immune system. Protease inhibitors likely play a critical role in host immune modulation thereby promoting parasite survival in this e...

Subject

Biology

Schistosoma mansoni

Serine protease

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