Rapid Hematopoietic Recovery After Coinfusion of Autologous-Blood Stem Cells and Culture-Expanded Marrow Mesenchymal Stem Cells in Advanced Breast Cancer Patients Receiving High-Dose Chemotherapy

N. Koç, Omer; L. Gerson, Stanton; Cooper, Brenda; M. Dyhouse, Stephanie; E. Haynesworth, Stephen; I. Caplan, Arnold; M. Lazarus, Hillard

doi:10.1200/jco.2000.18.2.307

Public

Rapid Hematopoietic Recovery After Coinfusion of Autologous-Blood Stem Cells and Culture-Expanded Marrow Mesenchymal Stem Cells in Advanced Breast Cancer Patients Receiving High-Dose Chemotherapy

Published in Journal of Clinical Oncology • Jan 1, 2000

Authors:

Omer N. Koç

Stanton L. Gerson

Brenda Cooper

Abstract

PURPOSE: Multipotential mesenchymal stem cells (MSCs) are found in human bone marrow and are shown to secrete hematopoietic cytokines and support hematopoietic progenitors in vitro. We hypothesized that infusion of autologous MSCs after myeloablative therapy would facilitate engraftment by hematopoi...

Subject

Medicine

Mesenchymal stem cell

Bone marrow

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