Role of lipid-bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics.

It is generally assumed that type A lantibiotics primarily kill bacteria by permeabilization of the cytoplasmic membrane. As previous studies had demonstrated that nisin interacts with the membrane-bound peptidoglycan precursors lipid I and lipid II, we presumed that this interaction could play a ro... View More