Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis

Tenzer, Stefan; Docter, Dominic; Rosfa, Susanne; Wlodarski, Alexandra; Kuharev, Jörg; Rekik, Alexander; K. Knauer, Shirley; Bantz, Christoph; Nawroth, Thomas; Bier, Carolin; Sirirattanapan, Jarinratn; J. Mann, Wolf; Treuel, Lennart; Zellner, R.; Maskos, Michael; Schild, Hansjörg; H. Stauber, Roland

doi:10.1021/nn201950e

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Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis

Published in ACS Nano • Aug 25, 2011

Authors:

Stefan Tenzer

Dominic Docter

Susanne Rosfa

Abstract

In biological fluids, proteins associate with nanoparticles, leading to a protein "corona" defining the biological identity of the particle. However, a comprehensive knowledge of particle-guided protein fingerprints and their dependence on nanomaterial properties is incomplete. We studied the long-l...

Subject

Nanoparticle

Particle size

Chemistry

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