Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial

C. Lindesmith, Lisa; T. Ferris, Martin; W. Mullan, Clancy; Ferreira, Jennifer; Debbink, Kari; Swanstrom, Jesica; C. Richardson, Charles; R. Goodwin, Robert; Baehner, Frank; M. Mendelman, Paul; F. Bargatze, Robert; S. Baric, Ralph

doi:10.1371/journal.pmed.1001807

Public

Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial

Published in PLoS Medicine • Mar 24, 2015

Authors:

Lisa C. Lindesmith

Martin T. Ferris

Clancy W. Mullan

Abstract

BACKGROUND: Human noroviruses (NoVs) are the primary cause of acute gastroenteritis and are characterized by antigenic variation between genogroups and genotypes and antigenic drift of strains within the predominant GII.4 genotype. In the context of this diversity, an effective NoV vaccine must elic...

Subject

Vaccination

Virology

Immunization

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