A Susceptibility Locus for Myopia in the Normal Population Is Linked to the PAX6 Gene Region on Chromosome 11: A Genomewide Scan of Dizygotic Twins

J. Hammond, Christopher; Andrew, Toby; T Mak, Y; D. Spector, Tim

doi:10.1086/423148

Public

A Susceptibility Locus for Myopia in the Normal Population Is Linked to the PAX6 Gene Region on Chromosome 11: A Genomewide Scan of Dizygotic Twins

Published in The American Journal of Human Genetics • Jun 29, 2004

Authors:

Christopher J. Hammond

Toby Andrew

Y T Mak

Abstract

Myopia is a common, complex trait with considerable economic and social impact and, in highly affected individuals, ocular morbidity. We performed a classic twin study of 506 unselected twin pairs and inferred the heritability of refractive error to be 0.89 (95% confidence interval 0.86-0.91). A gen...

Subject

Genetics

Locus (genetics)

Single-nucleotide polymorphism

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