Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

Iwamoto, Ryo; Yamazaki, Satoru; Asakura, Masanori; Takashima, Seiji; Hasuwa, Hidetoshi; Miyado, Kenji; Adachi, Satoshi; Kitakaze, Masafumi; Hashimoto, Koji; Raab, Gerhard; Nanba, Daisuke; Higashiyama, Shigeki; Hori, Masatsugu; Klagsbrun, Michael; Mekada, Eisuke

doi:10.1073/pnas.0537588100

Public

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

Published in Proceedings of the National Academy of Sciences • Mar 5, 2003

Authors:

Ryo Iwamoto

Satoru Yamazaki

Masanori Asakura

Abstract

The heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR) and the related receptor tyrosine kinase, ErbB4. HB-EGF-null mice (HB(del/del)) were generated to examine the role of HB-E...

Subject

Epidermal growth factor

Heparin-binding EGF-like growth factor

ErbB

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