Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans<sup>1</sup>

Date, Yukari; Kojima, Masayasu; Hosoda, Hiroshi; Sawaguchi, Akira; S. Mondal, Muhtashan; Suganuma, Tatsuo; Matsukura, Shigeru; Kangawa, Kenji; Nakazato, Masamitsu

doi:10.1210/endo.141.11.7757

Public

Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans1

Published in Endocrinology • Nov 1, 2000

Authors:

Yukari Date

Masayasu Kojima

Hiroshi Hosoda

Abstract

Ghrelin, a novel GH-releasing acylated peptide, was recently isolated from rat stomach. It stimulated the release of GH from the anterior pituitary through the GH secretagogue receptor (GHS-R). Ghrelin messenger RNA and the peptide are present in rat stomach, but its cellular source has yet to be de...

Subject

Ghrelin

Enteroendocrine cell

Internal medicine

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