Disrupted Pulmonary Vasculature and Decreased Vascular Endothelial Growth Factor, Flt-1, and TIE-2 in Human Infants Dying with Bronchopulmonary Dysplasia

Bhatt, Abhay; Pryhuber, Gloria; Huyck, Heidie; H. Watkins, Richard; A. Metlay, Leon; M. Maniscalco, William

doi:10.1164/ajrccm.164.10.2101140

Public

Disrupted Pulmonary Vasculature and Decreased Vascular Endothelial Growth Factor, Flt-1, and TIE-2 in Human Infants Dying with Bronchopulmonary Dysplasia

Published in American Journal of Respiratory and Critical Care Medicine • Nov 1, 2001

Authors:

Abhay Bhatt

Gloria Pryhuber

Heidie Huyck

Abstract

An abnormal pulmonary vasculature may be an important component of bronchopulmonary dysplasia (BPD). We examined human infant lung for the endothelial cell marker PECAM-1 and for angiogenic factors and their receptors. Lung specimens were collected prospectively at approximately 6 h after death. The...

Subject

Bronchopulmonary dysplasia

Medicine

Immunostaining

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