Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines.

J, Guillon; P, Grellier; M, Labaied; P, Sonnet; JM, Léger; R, Déprez-Poulain; I, Forfar-Bares; P, Dallemagne; N, Lemaître; F, Péhourcq; J, Rochette; C, Sergheraert; C, Jarry

doi:10.1021/jm0310840

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Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines.

Shared by NobleBlocks on Apr 1, 2004 • 12:00 AM UTC

Authors:

Guillon J

Grellier P

Labaied M

Abstract

Three pyrrolo[1,2-a]quinoxalines, 15 bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines were synthesized from various substituted nitroanilines or nitropyridines and tested for their in vitro activity upon the erythrocytic development ...

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